Friday, September 25, 2026
51 picks from Friday, September 25, 2026. Results included where graded.
- NFL
New England Patriots @ Jacksonville Jaguars
Under 45.5Game Totals Pick
by Caleb Wilfinger+108odds - MLB
Arizona Diamondbacks @ San Diego Padres
Moneyline - Arizona DiamondbacksThe visitors and playoff-chasers will give the ball to Brandon Pfaadt, who hasn’t been that much better than Mize in September with his 5.19 ERA. However, holding the Yankees to one run in 4.1 innings last week was encouraging, as is the fact that he has held the Padres to just 1 unearned run in his last two appearances (11.2 innings) against the club since the beginning of July.
by Sam Avellone+117odds - MLB
Cleveland Guardians @ Kansas City Royals
Moneyline - Cleveland GuardiansThe Guards aren’t the strongest against left-handers, but Jose Ramirez and David Fry have had success against Cameron, while Cleveland has been productive as a whole at the plate in high-pressure games over the last week. With Williams on the mound against an uninterested Royals lineup, I could only look to Cleveland here.
by Sam Avellone-133odds - NFL
Los Angeles Chargers @ Buffalo Bills
Under 50It's hard to find much to like with this Chargers offense at the moment, and Buffalo could settle into a more run-heavy game script once the Bills get an early lead. Regardless of which team covers this number, the under is my preferred look on the total.
by Caleb Wilfinger-108odds - MLB
Chicago Cubs @ Boston Red Sox
Moneyline - Chicago CubsMoney Line Pick
by Jason Fragomeni-113odds - MLB
Houston Astros @ Athletics
Run Line - Houston Astros -1.5Run Line Pick
by Jon Yaremko+100odds - MLB
Chicago Cubs @ Boston Red Sox
Under 6.5Game Totals Pick
by Sam Avellone-102odds - MLB
Texas Rangers @ Minnesota Twins
Moneyline - Texas RangersJacob deGrom has been solid this season with a 3.86 ERA in 158.2 innings. No in-depth analysis is needed for this game other than the Rangers will be desperate treating this as a must win game.
by Jon Yaremko-106odds - MLB
Los Angeles Dodgers @ San Francisco Giants
Los Angeles Dodgers Over 4.5The last time the Dodgers faced Yunior Marte, they put six runs up on the board through 4.2 innings. It also doesn't help that the Giants hold a 4.18 bullpen ERA, which will likely open the Dodgers up for more additional runs late in the game. While the Dodgers don't need to win this game, they want to give their starters plenty of playing time before having nearly a week off. Look for the Dodgers to come out swinging in this one.
by Jason Fragomeni+240odds - MLB
Los Angeles Angels @ Seattle Mariners
Moneyline - Los Angeles AngelsBryce Miller hasn't pitched six innings since July 2nd, so based on recent trends, it's unlikely he'll go deep in this game, especially since this game means nothing to either team. The Angels did steal one on the road last night, and Reid Detmers will look to put together one more quality start for the Angels before the season ends. With Seattle struggling against lefties, I'm not expecting their offense to do much early on.
by Jason Fragomeni+122odds - MLB
Baltimore Orioles @ New York Yankees
Moneyline - New York YankeesThe New York Yankees will start Brendan Beck who has pitched very well in AAA this season as a starter. Trevor Rogers is in decent form, but the Yankees are mashing lefties while Baltimore struggles against righties. Given offensive form and current pricing I side with New York in this game.
by Javan Shouey-142odds - MLB
New York Mets @ Washington Nationals
Moneyline - Washington NationalsThe New York Mets have yet to announce a starting pitcher but enter this game in horrible form against southpaw pitching. Andrew Alvarez is both a lefty and in good form, and I favor Washington given current information.
by Javan Shouey+117odds - MLB
Tampa Bay Rays @ Philadelphia Phillies
Moneyline - Tampa Bay RaysThe biggest question for the Phillies heading into this matchup is how far will Cristopher Sanchez go in this matchup. If the Phillies fend off the Diamondbacks, Sanchez will likely be the starter on Tuesday or Wednesday night, so they'll want to be cautious with how many innings he throws. Either way, this is a must win for the Phillies, but since they'll be a little extra cautious with Sanchez, they'll go to the bullpen early, which holds a 4.35 ERA, opening the door for the Rays to capitalize
by Jason Fragomeni+156odds - NFL
Los Angeles Chargers @ Buffalo Bills
Buffalo Bills -7Point Spread Pick
by Caleb Wilfinger+113odds - NFL
Minnesota Vikings @ Tampa Bay Buccaneers
Spread - Minnesota Vikings -1.5Minnesota is 2-0 with a defense allowing 12.5 points per game and tied for the league lead with eight sacks. Tampa Bay has allowed seven sacks, committed five turnovers and failed to cover 11 straight games, so I'm laying the short number with the Vikings.
by Luke Lindholm+106odds - NFL
Tennessee Titans @ New York Giants
Spread - Tennessee Titans +2.5Jaxson Dart is out for the regular season, so Jameis Winston starts on a short week, possibly without LT Andrew Thomas and pass rusher Brian Burns. Tennessee nearly beat Philadelphia last week, and former Giants head coach Brian Daboll now runs its offence.
by Luke Lindholm+100odds - NFL
Los Angeles Chargers @ Buffalo Bills
Spread - Buffalo Bills -7.5There are so many things wrong with this Chargers team on both sides of the ball, while Buffalo is healthy, in a groove offensively and coming off extra rest heading into its second consecutive home game. I'd need close to double digits to back Los Angeles here.
by Caleb Wilfinger+113odds - NFL
Kansas City Chiefs @ Miami Dolphins
Miami Dolphins +10.5Point Spread Pick
by Kevin Rogers-104odds - NFL
Minnesota Vikings @ Tampa Bay Buccaneers
Under 42.5Minnesota's defense has forced four takeaways, and the Vikings' offense has thrown for just 294 yards in two games. With Tampa Bay's drives stalling into field goals, I expect a low-scoring game.
by Luke Lindholm-104odds - NFL
Minnesota Vikings @ Tampa Bay Buccaneers
Minnesota Vikings -1.5Minnesota is 2-0 with a defense allowing 12.5 points per game and tied for the league lead with eight sacks. Tampa Bay has allowed seven sacks, committed five turnovers and failed to cover 11 straight games, so I'm laying the short number with the Vikings.
by Luke Lindholm+106odds - NFL
New England Patriots @ Jacksonville Jaguars
Jacksonville Jaguars -3The Jaguars are the much healthier team heading into this game, and they're also playing better football at the moment. Look for Trevor Lawrence and this Jacksonville offense to spread the ball around and make it difficult for New England's struggling offense to keep up.
by Caleb Wilfinger-102odds - NFL
Tennessee Titans @ New York Giants
Under 38.5Tennessee is averaging 15 points per game, and New York didn't score a touchdown on Monday after Dart went down. With both Titans starting running backs banged up and Winston running a new game plan, this should be a field-position game.
by Luke Lindholm-110odds - NFL
Tennessee Titans @ New York Giants
Tennessee Titans +2.5Jaxson Dart is out for the regular season, so Jameis Winston starts on a short week, possibly without LT Andrew Thomas and pass rusher Brian Burns. Tennessee nearly beat Philadelphia last week, and former Giants head coach Brian Daboll now runs its offence.
by Luke Lindholm-102odds - NFL
Los Angeles Chargers @ Buffalo Bills
Under 50.5It's hard to find much to like with this Chargers offense at the moment, and Buffalo could settle into a more run-heavy game script once the Bills get an early lead. Regardless of which team covers this number, the under is my preferred look on the total.
by Caleb Wilfinger-110odds - NFL
Los Angeles Chargers @ Buffalo Bills
Buffalo Bills -7.5There are so many things wrong with this Chargers team on both sides of the ball, while Buffalo is healthy, in a groove offensively and coming off extra rest heading into its second consecutive home game. I'd need close to double digits to back Los Angeles here.
by Caleb Wilfinger+106odds - NFL
Cincinnati Bengals @ Pittsburgh Steelers
Cincinnati Bengals -3.5There are probably tons of trends that point to the Steelers as home ‘dogs in this spot, but all that data would have been from Mike Tomlin’s tenure. He’s now in the studio with NBC, so that historical data is about as relevant as the head-to-head metrics from when Carson Palmer and Ben Roethlisberger were playing. As such, I have a hard time picking against Joe Burrow and this Cincinnati offense, paired with what appears to be a much-improved Bengals defense.
by Sam Avellone+108odds - NFL
Carolina Panthers @ Cleveland Browns
Carolina Panthers -2.5Watson looked passable last week, but it’s hard to find much confidence in that being a real thing considering what he has consistently put on tape the last few years. Meanwhile, Bryce Young has started to blossom under Dave Canales, and with Chuba Hubbard, Tetairoa McMillian, Jalen Coker and now Darren Waller at his disposal, he has all he needs to take advantage of a Cleveland defense that is 28th in success rate and 24th in EPA per play thus far.
by Sam Avellone-108odds - NFL
Kansas City Chiefs @ Miami Dolphins
Miami Dolphins +11It’s clear who is the better team in this matchup, but Kansas City is playing its first daytime game of the season following two primetime games and going on the road where it has struggled. KC should win, but Miami can at least keep this somewhat respectable.
by Kevin Rogers-104odds - MLB
Pittsburgh Pirates @ Detroit Tigers
Over 8Detroit's Jackson Jobe owns a 5.02 ERA to go along with a .281 BAA in three home starts, and the Pirates have been among the highest-scoring teams in baseball all season long. Pittsburgh's Bubba Chandler has seen his K/BB ratio drop from 7.8 last season to 1.8 this season.
by Connor Grootenhuis+100odds - MLBloss
Los Angeles Angels @ Seattle Mariners
Run Line - Seattle Mariners +1.5Seattle starting pitcher Bryan Woo owns a stellar 1.42 ERA through four starts and 25.1 innings of work in September. The Mariners are 4-0 in those games, and have won three by multiple runs. The Angels have lost 11 of Grayson Rodriguez's last 12 starts, and things won't get any easier going up against Woo tonight in Seattle.
by Connor Grootenhuis+223odds - NFL
New England Patriots @ Jacksonville Jaguars
Under 46New England should be looking to keep the ball on the ground and keep its defense off the field, while the Jaguars offense can be expected to be a bit more deliberate in their approach against a lot of conservative two-high safety looks from the Patriots defense.
by Caleb Wilfinger-110odds - NFL
New England Patriots @ Jacksonville Jaguars
Spread - Jacksonville Jaguars -3The Jaguars are the much healthier team heading into this game, and they're also playing better football at the moment. Look for Trevor Lawrence and this Jacksonville offense to spread the ball around and make it difficult for New England's struggling offense to keep up.
by Caleb Wilfinger-120odds - NFL
Seattle Seahawks @ Washington Commanders
Over 40.5This is one of the smallest numbers of the week, thus creating value on backing points. Drew Lock and Marcus Mariota are extremely capable backup quarterbacks and should be able to generate enough offense to send this total over.
by Ricky DimonEVENodds - NFL
Seattle Seahawks @ Washington Commanders
Seahawks -6.5Washington is 0-2 and quarterback Jayden Daniels once again suffered a dislocated elbow. Seattle is the defending Super Bowl champion and rolling along nicely at 2-0. The Seahawks should have little issue winning this one by at least a touchdown.
by Ricky Dimon-110odds - NFLloss
Atlanta Falcons @ Green Bay Packers
Under 48.5The Falcons have scored just 16 points across their two games this season, and although Michael Penix Jr. is set to come in at quarterback, that is unlikely to cause enough of a shift to send Atlanta into a scoring frenzy. Green Bay's defense has been solid, but the offense has been lackluster so far, with QB Jordan Love ranking last in pass completion percentage (52.11%). Go low on TNF.
by Chris FarleyEVENodds - NFLwin
Atlanta Falcons @ Green Bay Packers
Spread - Atlanta Falcons -19.5The Falcons have looked woeful through the first two weeks of the season, but the Packers haven't fared much better, and TNF could present a great buy-low opportunity on Atlanta. The Falcons' D ranks eighth in the NFL in yards per play allowed, and given the Packers failed to post 200 yards of offense against the Jets last week, there is reason to believe Atlanta can keep this one within a touchdown.
by Chris Farley-150odds - NFL
Atlanta Falcons @ Green Bay Packers
Tucker Kraft - Receptions Over 4.5Tucker Kraft entered the 2026 season hobbled, recovering from a torn ACL injury, and we were told his snap count would be managed to start the season. In Week 1, Kraft played 66% of the snaps. However, that was followed up in Week 2 with 98% of snaps against the Jets. TEs have had success this season against the Falcons, allowing the 3rd-most fantasy points in two weeks. I'm banking on Kraft stepping up this week.
by Bobby Stanley-110odds - MLB
Cincinnati Reds @ Toronto Blue Jays
Over 7.5Nick Lodolo has a 5.04 ERA in 103.2 innings. The Reds are averaging 5.1 runs allowed per game, which is 3rd worst in the league.
by Jon Yaremko-108odds - NFL
Baltimore Ravens @ Dallas Cowboys
Under 53Seven of the last eight international games have seen 50 points or fewer scored, and that trend should continue with this game in Brazil. Both teams looking vulnerable against the run. and if the offenses focus on their rushing attack, that should keep the clock ticking and lead to fewer possessions.
by Kevin Rogers+113odds - NFL
Houston Texans @ Indianapolis Colts
Over 42.5A total of 68 points were scored during the Week 18 finale between these two AFC South foes last season. Five of the last seven meetings between these two division rivals have produced at least 43 points.
by Ricky Dimon-108odds - NFLwin
Atlanta Falcons @ Green Bay Packers
Spread - Atlanta Falcons -5.5The Falcons have looked woeful through the first two weeks of the season, but the Packers haven't fared much better, and TNF could present a great buy-low opportunity on Atlanta. The Falcons' D ranks eighth in the NFL in yards per play allowed, and given the Packers failed to post 200 yards of offense against the Jets last week, there is reason to believe Atlanta can keep this one within a touchdown.
by Chris Farley-105odds - MLBloss
Houston Astros @ Athletics
Over 12.5With Barnett's struggles likely leading to plenty of scoring opportunities and both teams capable of adding on against the bullpens, this matchup projects to climb into double digits.
by Justin Ziolkowski+100odds - NFL
Las Vegas Raiders @ New Orleans Saints
Spread - Las Vegas Raiders +3It could be said that nobody saw the Saints coming this season, and they surprised a lot of us. However, I believe the same can and should be said about the Raiders. The difference is, only one of them comes with a field goal's worth of points at home.
by Aaron Taylor+100odds - NFLloss
Atlanta Falcons @ Green Bay Packers
Under 45.5The Falcons have scored just 16 points across their two games this season, and although Michael Penix Jr. is set to come in at quarterback, that is unlikely to cause enough of a shift to send Atlanta into a scoring frenzy. Green Bay's defense has been solid, but the offense has been lackluster so far, with QB Jordan Love ranking last in pass completion percentage (52.11%). Go low on TNF.
by Chris Farley-115odds - NFLwin
Atlanta Falcons @ Green Bay Packers
Spread - Atlanta Falcons +3.5The Falcons have looked woeful through the first two weeks of the season, but the Packers haven't fared much better, and TNF could present a great buy-low opportunity on Atlanta. The Falcons' D ranks eighth in the NFL in yards per play allowed, and given the Packers failed to post 200 yards of offense against the Jets last week, there is reason to believe Atlanta can keep this one within a touchdown.
by Chris Farley-105odds - NFL
Atlanta Falcons @ Green Bay Packers
Tucker Kraft - Receptions Over 5.5Tucker Kraft entered the 2026 season hobbled, recovering from a torn ACL injury, and we were told his snap count would be managed to start the season. In Week 1, Kraft played 66% of the snaps. However, that was followed up in Week 2 with 98% of snaps against the Jets. TEs have had success this season against the Falcons, allowing the 3rd-most fantasy points in two weeks. I'm banking on Kraft stepping up this week.
by Bobby Stanley+130odds - MLBwin
Houston Astros @ Athletics
Over 11With Barnett's struggles likely leading to plenty of scoring opportunities and both teams capable of adding on against the bullpens, this matchup projects to climb into double digits.
by Justin Ziolkowski-105odds - MLB
San Diego Padres @ Los Angeles Dodgers
Money Line Pick Underdog - San Diego PadresAt odds hovering around +150, the price, in combination with the contrasting form of the pitchers and the differing playoff scenarios, make me very interested in the Padres.
by Sam Avellone+153odds - MLBwin
Houston Astros @ Athletics
Game Totals Pick Over 11With Barnett's struggles likely leading to plenty of scoring opportunities and both teams capable of adding on against the bullpens, this matchup projects to climb into double digits.
by Justin Ziolkowski-108odds - MLBwin
Tampa Bay Rays @ New York Yankees
Game Totals Pick Over 6.5Neither team should throw their starter deep into this game. The Yankees will want Schlittler rested and sharp early next week, and Ian Seymour rarely works deep into games anyway. We should see a lot of relievers here, so I'll take the over on this unusually low game total.
by Chad Hartsock+125odds - MLB
Cleveland Guardians @ Boston Red Sox
Money Line Pick Underdog - Cleveland GuardiansSuarez is in fine form, but I question how long he will throw for with an imminent playoff appearance on deck. Boston seems to be cruising in neutral as a whole, as this offense has tallied more than one run just once in its last four games and hasn’t plated more than four runs since September 12.
by Sam Avellone+110odds