Wednesday, September 16, 2026
20 picks from Wednesday, September 16, 2026. Results included where graded.
- NFL
Detroit Lions @ Buffalo Bills
Over 54Whenever a total climbs and we see inflation like this, we look for reasons for why it might regress. In this case, the evidence supports another high-scoring affair. The Bills' offense looks as hot as ever, while the Lions will need to keep scoring to have any chance here. Expect fireworks on TNF.
by Chris Farley+104odds - MLB
San Diego Padres @ Colorado Rockies
Run Line - San Diego Padres -2.5With the Padres in excellent form, going up against a pitcher they’ve had plenty of success against in the past, I’m expecting a ninth San Diego victory in a row, this time by multiple runs.
by Sam Avellone-125odds - MLB
Baltimore Orioles @ New York Mets
Game Totals Pick Over 6.5Sean Manaea has allowed 4 or more earned runs in each of his last 5 starts and now faces a solid Orioles lineup. The Mets are crushing right-handed pitching, and Shane Baz has suspect aspects to his game.
by Javan Shouey+156odds - MLB
Detroit Tigers @ Toronto Blue Jays
Game Totals Pick Over 8.5The Tigers are scoring a steady 7.6 runs per game on their current 5-game win streak. On the other side, the Blue Jays are scoring over 6 runs per game on their current home stand. With both offenses rolling, runs could be coming early and often in this one.
by Connor Grootenhuis+111odds - MLBloss
Philadelphia Phillies @ Washington Nationals
Game Totals Pick Over 9.5Washington has been one of the better offenses against southpaws this season, sitting in the top three in average, on-base percentage and slugging. Philly hasn’t been quite as good, but they’re 15th in average and 11th in on-base percentage.
by Sam Avellone+210odds - MLBloss
Milwaukee Brewers @ Pittsburgh Pirates
Run Line - Milwaukee Brewers -5.5Jacob Misiorowski looks to make another imprint on his Cy Young campaign against a Pirates lineup in poor form. Lake Bacher opens a bullpen game for Pittsburgh against the Brewers, who are hitting both southpaws and righties well.
by Javan Shouey+250odds - MLBloss
Athletics @ Tampa Bay Rays
Game Totals Pick Over 3.5In his two starts since returning from the IL, Griffin Jax has given up four earned runs in 7.2 innings. Jack Perkins has been roughed up this season with a 6.53 ERA in 103.1 innings.
by Jon YaremkoEVENodds - MLBwin
Chicago White Sox @ Cleveland Guardians
Game Totals Pick Over 12.5Foster Griffin was rocked for 8 earned runs in his last start and now faces a White Sox lineup that is mashing southpaw pitching. Davis Martin has pitched better in his last 2 starts but allows a ton of hard contact, and the Guardians are in solid offensive form as well.
by Javan Shouey+146odds - UFC
T. Tuivasa @ R. Despaigne
R. DespaigneMoneyline
by Pickswise-750odds - UFC
M. Vera @ C. Jourdain
C. JourdainMoneyline
by Pickswise-230odds - UFC
A. Pantoja @ Joshua Van
Joshua VanMoneyline
by Pickswise-130odds - NFL
Philadelphia Eagles @ Tennessee Titans
Under 39.5It did not happen last week, but you have to think that Tennessee QB Cam Ward will make some strides in his second year. This is the smallest total (39.5) of the entire week in the NFL.
by Ricky Dimon+100odds - NFL
Philadelphia Eagles @ Tennessee Titans
Spread - Philadelphia Eagles -7Tennessee opened with a terrible 23-10 home loss to the Jets in Week 1, suggesting that it is the worst team in the entire NFL -- or maybe second worst ahead of Cleveland. Philadelphia (1-0) should roll.
by Ricky Dimon-108odds - MLB
New York Yankees @ Minnesota Twins
Run Line - New York Yankees -2.5Aaron Judge hit his first home run since returning from the IL, a promising sign for this Yankees lineup. This game is going to come down to the bullpen, and with the Yankees having the more powerful lineup and more arms available in the pen, I like New York to cruise to victory in this one.
by Jason Fragomeni-103odds - MLB
Baltimore Orioles @ New York Mets
Over 10.5Sean Manaea has allowed 4 or more earned runs in each of his last 5 starts and now faces a solid Orioles lineup. The Mets are crushing right-handed pitching, and Shane Baz has suspect aspects to his game.
by Javan Shouey+105odds - MLB
Detroit Tigers @ Toronto Blue Jays
Over 5.5The Tigers are scoring a steady 7.6 runs per game on their current 5-game win streak. On the other side, the Blue Jays are scoring over 6 runs per game on their current home stand. With both offenses rolling, runs could be coming early and often in this one.
by Connor Grootenhuis+130odds - MLBloss
Philadelphia Phillies @ Washington Nationals
Over 9.5Washington has been one of the better offenses against southpaws this season, sitting in the top three in average, on-base percentage and slugging. Philly hasn’t been quite as good, but they’re 15th in average and 11th in on-base percentage.
by Sam Avellone+130odds - MLBloss
Athletics @ Tampa Bay Rays
Over 5.5In his two starts since returning from the IL, Griffin Jax has given up four earned runs in 7.2 innings. Jack Perkins has been roughed up this season with a 6.53 ERA in 103.1 innings.
by Jon Yaremko+133odds - MLBwin
Chicago White Sox @ Cleveland Guardians
Over 9.5Foster Griffin was rocked for 8 earned runs in his last start and now faces a White Sox lineup that is mashing southpaw pitching. Davis Martin has pitched better in his last 2 starts but allows a ton of hard contact, and the Guardians are in solid offensive form as well.
by Javan Shouey+144odds - MLBwin
Los Angeles Dodgers @ Cincinnati Reds
Run Line - Los Angeles Dodgers -3.5After seeing Skubal yesterday, the Reds have to face Yamamoto today. Yamamoto is the most reliable arm in baseball, and only 3 times all season has he allowed 4+ runs in a game. Rhett Lowder seems to have hit the rookie wall, allowing 13 runs over his last 2 starts.
by Chad Hartsock-114odds